Cell Compositions and Methods for Hair Follicle Generation

On April 8 2011, Alvi Armani filed for US patent on Hair Multiplication& Regeneration.Where people are talking about it nowadays and calling it new technology , Alvi Armani has already done research in 2011.

Below is the brief description about the Patent :

 The application describes a method of generating a hair follicle, comprising administering a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells to the scalp of a mammal. The composition may optionally be administered with a hair growth agent and/or a carrier. The application also describes a composition comprising epidermal matrix cells, dermal papilla cells, dermal sheath cells and outer root sheath cells and the use of the composition to generate hair follicles.


CROSS REFERENCE TO RELATED APPLICATIONS This non-provisional application claims priority from U.S. provisional application US 61/353,272 filed on Jun. 10, 2010, which is incorporated herein by reference in its entirety.


The application relates to compositions and methods for generating hair follicles. In particular, the application relates to implanting in vitro-cultivated hair follicle cells into a scalp to generate and rejuvenate hair follicles in a subject suffering from hair loss.


Hair loss affects millions of people, including over 40% of men over the age of 30. Numerous factors can cause hair loss, including genetic predisposition, autoimmune reactions, scarring, diseases and infection. Hair loss can ultimately lead to complete baldness.

Alopecia is a medical condition in which hair is lost from an area of the body. One symptom of alopecia is hair follicle miniaturization (described below). Alopecia includes both androgenetic alopecia, also known as male pattern baldness, and alopecia areata, which is thought to be an autoimmune disorder.

Normally, a hair follicle cycles through phases including the anagen (growth) phase, the catagen (transition) phase and the telogen (resting or quiescent) phase. In the miniaturization process, the hair follicle enters a prolonged lag phase following the telogen stage. With successive anagen cycles, the follicles become smaller, leading to shorter, finer hair. The miniaturized follicle eventually produces a tiny hair shaft that is cosmetically insignificant. Ultimately, the follicle can stop producing a hair shaft altogether and the area of hair loss can become completely devoid of hair.

Several methods for treating hair loss are available, including drugs such as topical minoxidil and orally-delivered propecia. However, these treatments have achieved limited success in restoring natural hair growth and are only effective while the drugs are being taken.

One surgical treatment for hair loss is hair follicle transplantation, a procedure in which hair follicles are transplanted from a non-balding region of the scalp to a region of hair loss.

Alternatives to hair follicle transplantation are cell-based therapies whereby cells are implanted with the goal of developing new hair follicles. For example, U.S. Pat. No. 4,919,664 to Oliver et al. relates to a method of stimulating hair growth in the skin of a mammal by culturing at least one lower follicular dermal cell, and implanting the cultured cells in the epidermis. U.S. Pat. No. 6,399,057 to Gho describes a method of regenerating hair by: (1) removing hair in the anagen phase, (2) culturing hair follicle cells, and (3) implanting the cultured cells into bald regions. In addition, U.S. Patent Application No. 2007/0128172 to Yoshizato et al. describes the transplantation of cultured dermal papilla cells, dermal sheath cells and epidermal cells into the skin to regenerate hair. In Wu et al. (2006), cultured dermal papilla cells were mixed with outer root sheath cells and transplanted on the dorsal skin of nude mice to induce hair follicle and hair fiber formation.

There remains a need for efficient, cell-based therapies for rejuvenating miniaturized hair follicles and generating new hair follicles.

For more details of the Patent Filing please visit http://www.google.com/patents/US20110305671#legal-events

In the next post, we will post the result of the research so, stay tuned.

Treating Different types of hair loss


Hair loss can often be a traumatic experience leading to depression and low self-esteem among women. But are you aware of the types of hair loss, their causes and treatment options? Here’s a guide to different types of hair loss and how to treat them.

Types of hair loss

Androgenetic Alopecia: This is by far the most common type of hair loss suffered by both men and women due to genes and hormones. This genetic hair loss is hereditary and can be inherited from either from the mother or father’s side of the family. Commonly known as male and female pattern baldness, this type of hair loss is due to the action of a hormone known as dihydrotestosterone (DHT) which attacks the hair follicles and causes miniaturisation leading to permanent hair loss.

Telogen Effluvium: This condition is also referred to as diffuse hair loss. In this type of hair loss, a lot of hair fall occurs in a short span of time. The causes can be pregnancy, chemotherapy for cancer treatment, very high fever, severe illnesses, and sometimes even high levels of stress. This is not a permanent condition and most of the lost hair does grow back within a few months. Some sudden events that can contribute to this condition are childbirth, surgery, and severe emotional stress (death of loved ones, abuse, accidents, or other traumatic events.)

Alopecia Areata: 
Any sudden loss of hair resulting in bald patches is the condition of Alopecia Areata. This is an autoimmune disease where the hair follicles are attacked by the body. The reason as to why it happens has not yet been discovered. It can be a mild case and result in bald patches on the head or if it is severe it can affect the hair on the other parts of the body. This condition usually treats itself without any medication, although some doctors may prescribe certain steroid injections for repeated occurrence of localised Alopecia Areata.

Traction Alopecia: This type of hair loss occurs in people who routinely pull on their hair through harsh brushing or hairstyles such as a tight ponytail. Traction Alopecia can be found in Sikhs who wear a turban.

Other causes of hair loss: Other than the above mentioned causes, another common cause of hairloss is poor dietary habits. Lack of adequate nutrition due to crash dieting can lead to significant hairloss. Injury and certain skin diseases can also lead to permanent hair loss.

Hair loss treatments (FDA approved medication)

Minoxidil: Available as liquid or foam, it has to be rubbed on the scalp twice daily to grow hair and prevent hair loss. It takes around 12 weeks for new hair to start growing.

Finasteride: It is a prescribed medicine to treat male pattern baldness and has to be taken orally. Patients may experience slowing of hair loss and sometimes new growth. Rare side effects can be diminished by sex drive and sexual function. It should be avoided by women of child bearing age.


Hair transplant: This is the most effective way to treat the male pattern baldness or Androgenetic Alopecia where follicles are removed from the back portion of the scalp and transplanted in the hairloss areas. Earlier the process involved multiple session scars and stitches, but with the latest technique like Maximus Fue density, it can be restored in single session without cuts, pain or even scars.

Source : idiva.com